Protective effect of immunosuppressive treatment before orthotopic kidney autotransplantation

Are we going to start immunosuppresion prior to transplant if this translates?


Protective effect of immunosuppressive treatment before orthotopic kidney autotransplantation: "Publication year: 2010
Source: Transplant Immunology, In Press, Accepted Manuscript, Available online 27 October 2010
Federico, Cicora , Natalia, Lausada , Daniela N., Vasquez , Paola, Cicora , Guerrieri, Diego , ...
Background: Ischemia reperfusion injury (IRI) is one of the risk factors for delayed graft function, acute rejection and long term allograft survival after kidney transplantation. It's an independent antigen inflammatory process that produces tissue damage. Our objective was to study the impact of immunosuppressive treatment (IS) on IRI applying only one dose of IS before orthotopic kidney autotransplantation. Methods: Twenty-four rats allocated in four groups were studied. One group served as control (G1: autotransplanted rats without IS) and the rest received IS 12 h before kidney autotransplantation (G2: Rapamycin, G3: Mycophenolate mofetil and G4: Tacrolimus). Results: Improved renal function and systemic inflammatory response were found..."